Antequera, a judge, began his revolution legally in 1721 by affirming an impeachment the city council of Asuncion (Paraguay’s present-day capital) against the unpopular Spanish governor. Antequera, conveniently, also happened to be the guy who would succeed the unpopular territorial governor.
The conflict between the two would-be governors spiraled into a wider revolt for local autonomy pitting criollo settlers against the crown, though it would likely be overstating matters to call this a true bid for independence. One notable sore spot between the two parties was the prerogatives of Jesuit Reductions: these mission settlements for Christianizing natives (particularly prominent in Paraguay for the Guarani people) had originally been placed at the far fringes of Spain’s New World reach, and they enjoyed a wide autonomy, sustaining themselves economically with the yerba mate trade. For the Guarani, these were also welcome refuges from the brutal encomiendas; Guarani militias stoutly repelled slave raiders.
For these prerogatives, the Jesuits and the Guarani were loyal to the Spanish crown as against the local settlers better inclined to view the Reductions (and the potential slaves who inhabited them) as assets they’d like to get their own hands around. Antequera accordingly expelled the Jesuits near Asuncio and for a few years his word was law in Paraguay. Guarani troops mustered by the crown helped put the rebellion down, taking Antequera into custody and forwarding him to the notoriously severe Marquis of Castelfuerte, the Peruvian viceroy.
Society at Lima was in [Antequera’s] favor. Great efforts were made to delay his trial. But the viceroy was resolved to punish him, and sentence of death was passed. The judges, the university, the municipality, petitioned for pardon, as well as the people of all classes. The stern old marquis refused to listen, and Antequera was brought out for execution in the great square of Lima on July 5, 1731. There were cries for pardon, and the mob began to throw stones. Hearing the tumult, the viceroy came out on horseback and ordered his guards to fire. Antequera fell dead, as well as the two priests by his side, and several others. The viceroy then ordered the body to be taken to the scaffold and beheaded. His conduct received the approval of the king by decree of September, 1733. (Source)
The Spanish had not heard the end of Antequera.
During his imprisonment, Antequera befriended and inspired a fellow-prisoner named Fernando Mompo. After Antequera’s execution, Mompo returned to Paraguay brandishing the late rebel governor’s banner: “The authority of the commune is superior to that of the King himself!” Mompo launched a recrudescence of the comunero rebellion in the early 1730s. Mompo too shared Antequera’s fate.
A change in the political winds decades later led to the Spanish king Charles III himself expelling the Jesuits — and posthumously exonerating Jose de Antequera.